Houlihan M E, Pritchard W S, Robinson J H
Department of Physiology and Pharmacology, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, NC 27157, USA.
Psychopharmacology (Berl). 1996 Feb;123(3):231-8. doi: 10.1007/BF02246577.
In two separate experiments, P300 was recorded from overnight-abstaining smokers before and after smoking. In the first experiment, 32 subjects counted forward by ones and counted backwards by threes upon presentation of a rare tone burst (20%) in a stream of standard tones. There were no changes in P300 amplitude or latency pre- to post-smoking (1.1-mg FTC nicotine-yield cigarette). In the second experiment, 29 subjects completed auditory and visual oddball tasks before smoking, after smoking a low nicotine-yield cigarette (0.05 mg), after smoking a higher nicotine-yield cigarette (1.1-mg), and after smoking a second 1.1-mg cigarette. In the visual oddball task, P300 latency decreased after smoking the first higher-yield cigarette relative to both pre-smoking and post smoking the lower-yield cigarette. This effect was maintained after smoking the second higher-yield cigarette. In the visual task, P300 amplitude increased after smoking the first higher-yield cigarette (from a lower baseline level) in a group of subjects with larger changes in tidal-breath CO but not in a group with smaller changes in CO. There were no effects of smoking on P300 amplitude or latency in the auditory tasks of either the first or second experiment.
在两项独立实验中，对夜间戒烟的吸烟者在吸烟前后记录P300。在第一个实验中，32名受试者在一系列标准音调中出现罕见音调猝发（20%）时，依次正数和倒数三数。吸烟前至吸烟后（1.1毫克焦油量尼古丁卷烟），P300波幅或潜伏期无变化。在第二个实验中，29名受试者在吸烟前、吸低尼古丁含量卷烟（0.05毫克）后、吸高尼古丁含量卷烟（1.1毫克）后以及吸第二支1.1毫克卷烟后，完成听觉和视觉Oddball任务。在视觉Oddball任务中，吸第一支高尼古丁含量卷烟后，P300潜伏期相对于吸烟前和吸低尼古丁含量卷烟后均缩短。吸第二支高尼古丁含量卷烟后，这种效应依然存在。在视觉任务中，在潮气末二氧化碳变化较大的一组受试者中，吸第一支高尼古丁含量卷烟后（从较低基线水平开始）P300波幅增加，但在二氧化碳变化较小的一组受试者中则无此现象。在第一个或第二个实验的听觉任务中，吸烟对P300波幅或潜伏期均无影响。
