Fent K
Swiss Federal Institute for Environmental Science and Technology Dubendorf, Switzerland.
Crit Rev Toxicol. 1996 Jan;26(1):1-117.
Organotin compounds are ubiquitous contaminants in the environment. The high biological activity of some compounds toward aquatic organisms lead to deleterious impacts in aquatic ecosystems. Here, the aquatic ecotoxicology of organotins is reviewed based on a multidisciplinary approach involving environmental chemical, toxicological, and ecological aspects. Basic results were obtained both with field and laboratory studies, and some of the most important recent results and conclusions are critically reviewed. The contamination of and fate in aquatic systems is reported and linked with effects at different levels of biological organization. Major emphasis is placed on the development of a concept of ecotoxicology that encompasses not only effect assessment alone, but also integrates environmental chemistry with aquatic toxicology. Thereby, the influence of speciation for bioavailability, basic modes of toxic action, and aquatic toxicity are discussed. This case study on organotins allows to a certain extent generalizations to ecotoxicology in general.
有机锡化合物是环境中普遍存在的污染物。一些化合物对水生生物具有高生物活性,会对水生生态系统产生有害影响。在此,基于涉及环境化学、毒理学和生态学方面的多学科方法,对有机锡的水生生态毒理学进行综述。通过现场和实验室研究均获得了基础结果,并对一些最重要的近期结果和结论进行了批判性审视。报告了水生系统中的污染情况和归宿,并将其与不同生物组织水平的影响联系起来。主要重点在于发展一种生态毒理学概念,该概念不仅包括单独的效应评估,还将环境化学与水生毒理学相结合。由此,讨论了形态对生物可利用性、基本毒性作用模式和水生毒性的影响。这个关于有机锡的案例研究在一定程度上允许对一般生态毒理学进行概括。