da Costa Charles S, Alahmadi Hanin, Warner Genoa R, Nunes Maria Tereza, Dias Glaecir Roseni Mundstock, Miranda-Alves Leandro, Graceli Jones B
Universidade Federal do Espírito Santo Departamento de Morfologia VitóriaES Brasil Departamento de Morfologia, Universidade Federal do Espírito Santo, Vitória, ES, Brasil.
New Jersey Institute of Technology Department of Chemistry and Environmental Science NewarkNJ USA Department of Chemistry and Environmental Science, New Jersey Institute of Technology, Newark, NJ, USA.
Arch Endocrinol Metab. 2024 Nov 6;68(Spec Issue):e240186. doi: 10.20945/2359-4292-2024-0186. eCollection 2024.
Tributyltin (TBT) is an organotin compound and a common persistent environmental pollutant with endocrine-disrupting chemical (EDC) actions. It can accumulate in the environment at various concentrations throughout the food chain in the ecosystem, posing a risk to human health, especially during critical periods such as gestation and fetal and offspring development. In this review, we report the results of studies describing the consequences of TBT exposure on placental and reproductive parameters in offspring of both sexes. Results from and studies clearly indicate that TBT causes adverse effects on placental development and reproductive parameters in offspring. However, substantial knowledge gaps remain in the literature, requiring further research to better understand the mechanisms behind TBT effects on placental and reproductive disruption in offspring.
三丁基锡（TBT）是一种有机锡化合物，是一种常见的具有内分泌干扰化学（EDC）作用的持久性环境污染物。它可以在生态系统的食物链中以各种浓度在环境中积累，对人类健康构成风险，尤其是在妊娠、胎儿和后代发育等关键时期。在本综述中，我们报告了描述TBT暴露对两性后代胎盘和生殖参数影响的研究结果。[具体研究]和[具体研究]的结果清楚地表明，TBT对后代的胎盘发育和生殖参数有不利影响。然而，文献中仍存在大量知识空白，需要进一步研究以更好地理解TBT对后代胎盘和生殖干扰作用背后的机制。
