在豚鼠身上用铍合金样本进行斑贴试验。
Patch testing with beryllium alloy samples in guinea pigs.
作者信息
Zissu D, Binet S, Cavelier C
机构信息
Institut National de Recherche et de Securite, Vandoeuvre, France.
出版信息
Contact Dermatitis. 1996 Mar;34(3):196-200. doi: 10.1111/j.1600-0536.1996.tb02173.x.
An experimental study was conducted in guinea pigs for the predictive assessment of the beryllium alloy hazard in occupational exposure of the skin to beryllium compounds. Guinea pigs were sensitized to beryllium sulfate according to the maximized Magnusson and Kligman test, and challenged with beryllium alloys and metallic copper, beryllium and aluminum samples. Results showed a delayed skin hypersensitivity reaction in 30 to 60% of pre-sensitized guinea pigs challenged with copper-beryllium alloys and aluminum-beryllium alloy. An inflammatory follicular reaction was induced by copper in both controls and pre-sensitized guinea pigs.
进行了一项针对豚鼠的实验研究，以预测职业性皮肤接触铍化合物时铍合金的危害。根据改良的Magnusson和Kligman试验使豚鼠对硫酸铍致敏，并用铍合金、金属铜、铍和铝样品进行激发。结果显示，30%至60%预先致敏的豚鼠在用铜铍合金和铝铍合金激发后出现延迟性皮肤过敏反应。在对照组和预先致敏的豚鼠中，铜均诱发了滤泡性炎症反应。
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