Adams J B, Moore R G, Anderson J H, Strandberg J D, Marshall F F, Davoussi L R
Department of Urology, Johns Hopkins University, Baltimore, MD, USA.
J Endourol. 1996 Feb;10(1):71-5. doi: 10.1089/end.1996.10.71.
High-intensity focused ultrasound (HIFU) is a noninvasive surgical technique in which ultrasound energy is delivered transcutaneously to a discrete area within the body. This energy can result in a well-defined zone of cellular death within the targeted tissue. We used HIFU in an effort to ablate rabbit VX-2 kidney tumors. A tumor cell suspension was injected into a renal segmental artery (Phase 1, nine rabbits) or directly into the lower pole parenchyma (Phase 2, nine rabbits). After a 2-week incubation period, open direct contact (Phase 1) or transcutaneous ablation (Phase 2) was performed. In Phase 1, after sonablation, there was pathologic evidence of tissue destruction in nine animals, and seven had both gross and histologic evidence of tumor ablation. There was sharp demarcation between viable and ablated tissue. In Phase 2, pathologic evidence of kidney ablation was seen in seven of nine animals. However, only two rabbits showed the well-demarcated effects of ablation in the tumor. High-intensity focused ultrasound can be effective at causing cell death in renal tumors and surrounding renal tissue. However, with the present ultrasound technology, imaging of renal lesions in the rabbit model is not adequate to consistently localize and completely ablate tumor.
高强度聚焦超声（HIFU）是一种非侵入性手术技术，通过经皮将超声能量传递到体内的一个离散区域。这种能量可导致靶组织内出现明确的细胞死亡区域。我们使用HIFU来消融兔VX-2肾肿瘤。将肿瘤细胞悬液注入肾段动脉（第1阶段，9只兔）或直接注入下极实质（第2阶段，9只兔）。经过2周的潜伏期后，进行开放直接接触消融（第1阶段）或经皮消融（第2阶段）。在第1阶段，超声消融后，9只动物有组织破坏的病理证据，7只动物有肿瘤消融的大体和组织学证据。存活组织与消融组织之间有明显的界限。在第2阶段，9只动物中有7只出现了肾脏消融的病理证据。然而，只有2只兔的肿瘤显示出界限分明的消融效果。高强度聚焦超声可有效导致肾肿瘤及周围肾组织的细胞死亡。然而，就目前的超声技术而言，兔模型中肾病变的成像不足以持续定位并完全消融肿瘤。
