超声引导下对兔肾移植VX-2癌进行微波热疗。

Ultrasound-guided microwave thermotherapy on a VX-2 carcinoma implanted in rabbit kidney.

作者信息

Kigure T, Harada T, Yuri Y, Satoh Y

机构信息

Department of Urology, Akita University School of Medicine, Japan.

出版信息

Ultrasound Med Biol. 1995;21(5):649-55. doi: 10.1016/0301-5629(95)00008-f.

DOI:10.1016/0301-5629(95)00008-f

PMID:8525555

Abstract

A temperature greater than 60 degrees C was maintained for 60 s within a 5-mm radius of a microwave electrode implanted in a rabbit kidney using 2450 MHz at 100 W for 30 s. Histological examination revealed complete coagulation necrosis in that area. VX-2 cells were inoculated into the kidneys of 10 rabbits. One week later, five rabbits received ultrasound-guided microwave thermotherapy, and the remaining five rabbits received no treatment. All rabbits with microwave thermotherapy had a complete response to treatment while all rabbits without therapy died of cancer within 6 weeks of the VX-2 implantation. These results indicate that ultrasound-guided microwave thermotherapy has the potential of being a nephron-salvaging treatment for small renal tumors.

摘要

使用2450兆赫、100瓦的功率，在植入兔肾的微波电极5毫米半径范围内，将温度维持在60摄氏度以上60秒，持续30秒。组织学检查显示该区域出现完全性凝固性坏死。将VX - 2细胞接种到10只兔子的肾脏中。一周后，五只兔子接受超声引导下的微波热疗，其余五只兔子不接受治疗。所有接受微波热疗的兔子对治疗均有完全反应，而所有未接受治疗的兔子在VX - 2植入后6周内死于癌症。这些结果表明，超声引导下的微波热疗有可能成为治疗小肾肿瘤的保留肾单位治疗方法。