高强度聚焦超声治疗复发性和转移性腹部肿瘤患者的并发症
Complications of high intensity focused ultrasound in patients with recurrent and metastatic abdominal tumors.
作者信息
Li Jian-Jun, Xu Guo-Liang, Gu Mo-Fa, Luo Guang-Yu, Rong Zhang, Wu Pei-Hong, Xia Jian-Chuan
机构信息
Department of HIFU, Cancer Center, Sun Yat-sen University, National Key Laboratory of Oncology, 651, Dongfengdong Road, Guangzhou 510060, Guangdong Province, China.
出版信息
World J Gastroenterol. 2007 May 21;13(19):2747-51. doi: 10.3748/wjg.v13.i19.2747.
AIM
To analyze the local and systemic complications of high intensity focused ultrasound (HIFU) for patients with recurrent and metastatic abdominal tumors.
METHODS
From Aug 2001 to Aug 2004, 17 patients with recurrent and metastatic abdominal tumors were enrolled in this study. Real-time sonography was taken, and vital signs, liver and kidney function, skin burns, local reactions, and systemic effects were observed and recorded before, during, and after HIFU. CT and MRI were also taken before and after HIFU.
RESULTS
All 17 patients had skin burns and pain in the treatment region; the next common complication was neurapraxia of the stomach and intestines to variable degrees. The other local and systemic complications were relatively rare. Severe complications were present in two patients; one developed a superior mesenteric artery infarction resulting in necrosis of the entire small intestines, and the other one suffered from a perforation in terminal ileum due to HIFU treatment.
CONCLUSION
Although HIFU is a one of noninvasive treatments for the recurrent and metastatic abdominal tumors, there are still some common and severe complications which need serious consideration.
目的
分析高强度聚焦超声（HIFU）治疗复发性和转移性腹部肿瘤患者的局部及全身并发症。
方法
2001年8月至2004年8月，本研究纳入17例复发性和转移性腹部肿瘤患者。进行实时超声检查，并在HIFU治疗前、治疗期间和治疗后观察并记录生命体征、肝肾功能、皮肤烧伤、局部反应及全身影响。HIFU治疗前后还进行了CT和MRI检查。
结果
17例患者均出现治疗区域皮肤烧伤及疼痛；其次常见的并发症是不同程度的胃肠神经失用。其他局部和全身并发症相对少见。2例患者出现严重并发症；1例发生肠系膜上动脉梗死，导致整个小肠坏死，另1例因HIFU治疗出现回肠末端穿孔。
结论
尽管HIFU是复发性和转移性腹部肿瘤的无创治疗方法之一，但仍存在一些常见且严重的并发症，需要认真考虑。
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