Yang X F, Lee B L, New A L, Ong H Y, Ma L, Zhang Q, Ong C N
Department of Community, Occupational and Family Medicine, National University of Singapore.
Am J Ind Med. 1996 Mar;29(3):269-74. doi: 10.1002/(SICI)1097-0274(199603)29:3<269::AID-AJIM6>3.0.CO;2-L.
Homovanillic acid (HVA) and vanillylmandelic acid (VMA), two end products of dopamine metabolism, were measured in 60 workers exposed to carbon disulfide (CS(2)) in a rayon factory and in 48 unexposed workers. The airborne CS(2) concentrations in eight major exposure zones of the plant were measured monthly over a period of 4 years, from 1990 to 1994. In addition, the exposure concentrations and exposure history of each worker were integrated to estimate the overall lifetime exposure. Industrial hygiene data showed that the geometric mean concentrations of CS(2) in the plant ranged from 2.68 to 20.19 ppm, and more than 15% of the studied population had been repeatedly exposed to CS(2) at concentrations exceeding the ACGIH recommended time-weighted average of 10 ppm. The results showed that there was a significantly lower level and a higher proportion of CS(2) workers with decreased HVA and VMA excretion. However, there were no statistical correlations between the two dopaminergic metabolites and the mean CS(2) concentration, and years of employment. In contrast, significant dose-effect relationships were observed between these two metabolites and the integrated cumulative exposure (ICE) variable. The correlation coefficients for ICE and HVA, and ICE and VMA were -0.35 (p < 0.01) and -0.20 (p <0.05), respectively. These data suggest that chronic exposure to CS(2) was associated with measurable reduction in catecholamine metabolite concentrations. This finding is compatible with the earlier observations in laboratory animals that CS(2) exposures interfere with neurochemical metabolism.
对一家人造丝工厂中60名接触二硫化碳（CS₂）的工人以及48名未接触的工人，测定了多巴胺代谢的两种终产物高香草酸（HVA）和香草扁桃酸（VMA）。在1990年至1994年的4年时间里，每月对该工厂八个主要暴露区域的空气中CS₂浓度进行测量。此外，整合每位工人的暴露浓度和暴露史以估算其一生的总暴露量。工业卫生数据显示，该工厂CS₂的几何平均浓度在2.68至20.19 ppm之间，超过15%的研究人群曾反复暴露于超过美国政府工业卫生学家会议（ACGIH）建议的10 ppm时间加权平均值的CS₂浓度环境中。结果显示，接触CS₂的工人中，HVA和VMA排泄量降低的水平显著更低，比例更高。然而，这两种多巴胺能代谢产物与CS₂平均浓度以及工作年限之间均无统计学相关性。相反，在这两种代谢产物与综合累积暴露（ICE）变量之间观察到显著的剂量 - 效应关系。ICE与HVA以及ICE与VMA的相关系数分别为 -0.35（p < 0.01）和 -0.20（p < 0.05）。这些数据表明，长期接触CS₂与儿茶酚胺代谢产物浓度的可测量降低有关。这一发现与早期在实验动物中的观察结果一致，即接触CS₂会干扰神经化学代谢。
