[慢性肾衰竭透析前患者血液中腺嘌呤核苷酸的浓度]
[Concentration of adenine nucleotides in blood of predialysis patients with chronic renal failure].
作者信息
Bułło B, Marlewski M, Manitius J, Smoleński R T, Rutkowski B
机构信息
Z Kliniki Chorób Nerek Akademii Medycznej w Gdańsku.
出版信息
Pol Arch Med Wewn. 1995 Nov;94(5):389-94.
Intraerythrocyte and blood level ATP concentration is increased in CRF. But little is known on the blood concentration of ADP and AMP in CRF. HPLC was applied to evaluate the ATP, ADP, AMP concentration in blood of 25 CRF patients, with serum creatinine from 2.4 mg/dl to 14.4 mg/dl treated conservatively. Controls were healthy people, with normal renal function. In CRF ATP was higher (p < 0.001) and ADP, AMP and hypoxanthine were lower (p < 0.001) then in controls. Also ATP correlated (r = 0.78; p < 0.001) with serum phosphate and (r = 0.40; p < 0.05) with serum creatinine in CRF patients. Adenine nucleotides turnover is increased in CRF and this process is related to severity of the disease.
慢性肾功能衰竭（CRF）患者红细胞内及血液中的ATP浓度升高。但关于CRF患者血液中ADP和AMP浓度的情况却知之甚少。应用高效液相色谱法（HPLC）评估了25例接受保守治疗、血清肌酐水平在2.4mg/dl至14.4mg/dl之间的CRF患者血液中的ATP、ADP、AMP浓度。对照组为肾功能正常的健康人。与对照组相比，CRF患者的ATP水平较高（p<0.001），而ADP、AMP和次黄嘌呤水平较低（p<0.001）。此外，在CRF患者中，ATP与血清磷酸盐相关（r=0.78；p<0.001），与血清肌酐相关（r=0.40；p<0.05）。CRF患者的腺嘌呤核苷酸周转率增加，且这一过程与疾病的严重程度相关。
Zotero 插件