[脉络膜黑色素瘤患者血清中α-1抗胰蛋白酶水平的研究]
[Investigations of alpha-1-antitrypsin level in blood serum of patients with melanoma of the choroid].
作者信息
Matysik A, Jakubowska-Solarska B, Toczołowski J
机构信息
Z II Kliniki Okulistyki AM w Lublinie.
出版信息
Klin Oczna. 1995 Sep-Oct;97(9-10):273-5.
PURPOSE
To assess alpha-1-antitrypsin concentration in blood serum of patients with melanoma of the choroid.
MATERIAL AND METHODS
35 patients (14 women and 21 men) were examined. The control group comprised 12 healthy persons. Tests of alpha-1-antitrypsin level were performed using immunologicresponse produced by diagnostic antibodies with the antigen present in the studied seru. Behring Nor-Partigen platelets were used for determinations. The results were statistically analysed using Cohran-Cox test.
RESULTS
The investigations have shown, in patients with melanoma of the choroid, the level of alpha-1-antitrypsin amounts, on the average, to 296 75.5 mg/dl. In the control group, however, it was 219 50.1 mg/dl. The statistical significance was p < 0.001.
CONCLUSION
A considerably higher level of glycoprotein in patients with melanoma of the choroid suggests the usefulness of determining alpha-1-antitrypsinlevel on recognising neoplasms of the visual system.
目的
评估脉络膜黑色素瘤患者血清中的α-1抗胰蛋白酶浓度。
材料与方法
对35例患者（14名女性和21名男性）进行了检查。对照组包括12名健康人。使用诊断抗体与研究血清中存在的抗原产生的免疫反应来检测α-1抗胰蛋白酶水平。使用贝林诺-帕蒂根血小板进行测定。结果采用 Cochr an-Cox检验进行统计学分析。
结果
研究表明，脉络膜黑色素瘤患者的α-1抗胰蛋白酶水平平均为296±75.5mg/dl。然而，对照组的该水平为219±50.1mg/dl。统计学显著性为p<0.001。
结论
脉络膜黑色素瘤患者中糖蛋白水平显著更高，这表明测定α-1抗胰蛋白酶水平对识别视觉系统肿瘤有用。
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