Tekşen F, Mungan D, Sayal A, Misurligil Z, Aydin A, Gürbüz L, Işimer A, Demirel Y S, Acican T, Sin B
Department of Pulmonary Medicine, University of Ankara, Turkey.
Respiration. 1996;63(1):25-7. doi: 10.1159/000196511.
In the present study, selenium (Se), copper (Cu), zinc (Zn), and magnesium (Mg) levels in serum and pleural fluid from patients with malignant and nonmalignant pleural diseases were measured and compared with serum concentrations in healthy subjects. Serum/pleural fluid ratios were also calculated for each element. The purpose of this study was to evaluate the diagnostic value of trace metals, especially Se, in neoplastic and nonneoplastic pleural diseases. Serum Cu and Mg levels were significantly higher in both malignant and nonmalignant groups of patients when compared with control subjects (p < 0.05). However, serum levels of these elements did not show a significant difference between malignant and nonmalignant cases (p > 0.05). The serum/pleural fluid ratio of Zn was significantly lower in patients with malignant effusions than in benign conditions (p = 0.05). Serum and pleural fluid Se, Cu, Zn and Mg levels were not significantly different between the two groups (p > 0.05). Thus, Se, Cu, Zn, and Mg seem to have no diagnostic value for distinguishing malignant from nonmalignant effusions.
在本研究中，对患有恶性和非恶性胸膜疾病患者的血清及胸腔积液中的硒（Se）、铜（Cu）、锌（Zn）和镁（Mg）水平进行了测定，并与健康受试者的血清浓度进行比较。还计算了每种元素的血清/胸腔积液比值。本研究的目的是评估痕量金属，尤其是硒，在肿瘤性和非肿瘤性胸膜疾病中的诊断价值。与对照组相比，恶性和非恶性患者组的血清铜和镁水平均显著更高（p < 0.05）。然而，这些元素的血清水平在恶性和非恶性病例之间未显示出显著差异（p > 0.05）。恶性胸腔积液患者的锌血清/胸腔积液比值显著低于良性情况（p = 0.05）。两组之间的血清及胸腔积液硒、铜、锌和镁水平无显著差异（p > 0.05）。因此，硒、铜、锌和镁对于区分恶性与非恶性胸腔积液似乎没有诊断价值。
