Gagneten D, Hijazi Y M, Jaffe E S, Solomon D
Laboratory of Pathology, National Institutes of Health, Bethesda, MD 20892, USA.
Diagn Cytopathol. 1996 Feb;14(1):32-7. doi: 10.1002/(SICI)1097-0339(199602)14:1<32::AID-DC7>3.0.CO;2-X.
Mantle cell lymphoma (MCL) is a rare type of non-Hodgkin's lymphoma which is thought to derive from the cuff of the lymphoid follicle. The histopathologic and immunophenotypic features of MCL are well described. The literature contains few cytopathologic studies of collected cases of MCL. Review of files from the National Institutes of Health from 1989 through June 1993 revealed a total of 24 positive specimens from eight patients with a diagnosis of MCL. The specimens consisted of ten pleural effusions, ten cerebrospinal fluids (CSF), and four fine-needle aspirations. CSF involvement was noted in 3 of 8 (37.5%) patients and was associated with disease progression. The cardinal morphologic features on air-dried, Diff-Quik-stained material are a monotonous population of relatively small atypical lymphoid cells with enlarged, frequently grooved nuclei, coarse chromatin and small nucleoli, scant cytoplasm, and an absence of large or "transformed" lymphoid cells. Immunocytochemistry is characterized by expression of one or more pan-B-cell markers, immunoglobulin light-chain restriction, and positivity for the pan-T-cell antigen CD5. When these morphologic and immunocytochemical characteristics are present, the specific diagnosis of MCL can be suggested on cytologic specimens.
套细胞淋巴瘤（MCL）是一种罕见的非霍奇金淋巴瘤，被认为起源于淋巴滤泡的套区。MCL的组织病理学和免疫表型特征已有详尽描述。关于收集到的MCL病例的细胞病理学研究文献较少。回顾美国国立卫生研究院1989年至1993年6月的档案，共发现8例诊断为MCL患者的24份阳性标本。标本包括10份胸腔积液、10份脑脊液（CSF）和4份细针穿刺样本。8例患者中有3例（37.5%）出现脑脊液受累，且与疾病进展相关。在空气干燥、Diff-Quik染色的材料上，主要形态学特征是相对较小的非典型淋巴细胞群，细胞核增大且常有沟，染色质粗糙，核仁小，细胞质稀少，且无大的或“转化”的淋巴细胞。免疫细胞化学的特征是一种或多种泛B细胞标志物的表达、免疫球蛋白轻链限制以及泛T细胞抗原CD5阳性。当出现这些形态学和免疫细胞化学特征时，可在细胞学标本上提示MCL的明确诊断。
