Soini Y, Pääkkö P
Department of Pathology, University of Oulu, Finland.
Histopathology. 1996 Feb;28(2):141-5. doi: 10.1046/j.1365-2559.1996.288334.x.
bcl-2 is a proto-oncogene which inhibits apoptosis. In contrast, p53 tumour suppressor gene is known to induce apoptosis. In this study we analysed immunohistochemically 63 mesenchymal tumours for the expression of bcl-2 and p53 proteins with a special emphasis on muscle-derived tumours. bcl-2 was expressed in all seven rhabdomyosarcomas and in five out of seven leiomyosarcomas. In benign muscle tumours, bcl-2 expression was found in all four epithelioid leiomyomas and in six out of 14 leiomyomas. In non-neoplastic muscle cells, occasional weak bcl-2 positivity was found in muscle cells of vascular walls and myometrium. In mesenchymal tumours of other lineages, bcl-2 positivity was only found in four out of 12 malignant fibrous histiocytomas and in one out of three liposarcomas. p53 positivity was found in 14 tumours, 13 of which were sarcomas. No association was found between p53 and bcl-2 positivity. Our results suggest that bcl-2 expression is activated significantly more often in muscle derived tumours than in mesenchymal tumours of other lineages. Our results also suggest that p53 status does not directly affect the expression of bcl-2 in sarcomas.
bcl-2是一种抑制细胞凋亡的原癌基因。相比之下，已知p53肿瘤抑制基因可诱导细胞凋亡。在本研究中，我们采用免疫组织化学方法分析了63例间叶组织肿瘤中bcl-2和p53蛋白的表达情况，特别关注了肌肉来源的肿瘤。bcl-2在所有7例横纹肌肉瘤以及7例平滑肌肉瘤中的5例中表达。在良性肌肉肿瘤中，所有4例上皮样平滑肌瘤以及14例平滑肌瘤中的6例均发现有bcl-2表达。在非肿瘤性肌肉细胞中，仅在血管壁和子宫肌层的肌肉细胞中偶尔发现弱bcl-2阳性。在其他谱系的间叶组织肿瘤中，仅在12例恶性纤维组织细胞瘤中的4例以及3例脂肪肉瘤中的1例中发现bcl-2阳性。在14例肿瘤中发现p53阳性，其中13例为肉瘤。未发现p53阳性与bcl-2阳性之间存在关联。我们的结果表明，与其他谱系的间叶组织肿瘤相比，bcl-2表达在肌肉来源的肿瘤中更常被显著激活。我们的结果还表明，p53状态并不直接影响肉瘤中bcl-2的表达。
