Gracheva N D, Mirzaev M A
Zh Vopr Neirokhir Im N N Burdenko. 1977 May-Jun(3):7-13.
In 184 rabbits experiments it was demonstrated that debridement with suction of the damaged portion of the brain within the macroscopically intact brain tissue and a leak-proof suture undertaken on the 1st and 3rd day following a penetrating skull-brain trauma in irradiated with 400 r and non-irradiated animals prevents heamorrhagic and purulent complications, permits primary healing of the wound, and a nearly 100% survival of the animals. The irradiated animals without debridement died in 67% of cases, non-irradiated--in 43%. Debridement limited to wound debris washing-out failed to free the irradiated animals from purulent complications, but prevented the development of cerebral haematomas, the mortality being reduced to 40%. In the non-irradiated animals such debridement did not alter the mortality figures.
在184只兔子的实验中表明,在穿透性颅脑创伤后的第1天和第3天,对经400伦琴照射和未照射的动物,在宏观上完整的脑组织内对受损脑部分进行吸引清创并进行防漏缝合,可预防出血性和化脓性并发症,使伤口一期愈合,并使动物存活率接近100%。未进行清创的受照射动物67%死亡,未受照射的动物43%死亡。仅限于冲洗伤口碎片的清创未能使受照射动物免于化脓性并发症,但可预防脑血肿的发生,死亡率降至40%。在未受照射的动物中,这种清创并未改变死亡率。