Domingo S, Gamazo C
Dpto. de Microbiología, Universidad de Navarra, Pamplona, Spain.
J Chemother. 1996 Feb;8(1):55-8. doi: 10.1179/joc.1996.8.1.55.
The activities of therapeutic regimens with azithromycin (AZI) and doxycycline combined with streptomycin (DOX-SM) were compared in Brucella melitensis infected mice. In a chronic model, AZI given over 10, 14 or 21 consecutive days (50 mg/kg/24 h) significantly reduced the infection (1.3-1.6 logs, day 48 post-infection). However, the effectiveness of DOX (21 days, 50 mg/kg/12 h) was higher than AZI (3.4 logs of reduction, day 48 post-infection). Besides, when DOX was administered for 45 days, it "cured" all the animals from day 78. Similar results were obtained in an acute model infection. One single dose of DOX or DOX-SM, starting one day after lethal challenge, was able to protect 83% of the mice. In contrast, only 25% of the mice treated with AZI (50-200 mg/Kg) survived the challenge. Our findings demonstrate that AZI, in contrast to DOX-SM, does not cure experimental brucellosis.
在感染了羊种布鲁氏菌的小鼠中，比较了阿奇霉素（AZI）和强力霉素联合链霉素（DOX-SM）治疗方案的活性。在慢性模型中，连续10、14或21天给予阿奇霉素（50mg/kg/24h）可显著降低感染（感染后48天减少1.3-1.6个对数）。然而，强力霉素（21天，50mg/kg/12h）的效果高于阿奇霉素（感染后48天减少3.4个对数）。此外，当给予强力霉素45天时，从第78天起所有动物均“治愈”。在急性模型感染中也获得了类似结果。在致死性攻击后一天开始，单次给予强力霉素或强力霉素-链霉素能够保护83%的小鼠。相比之下，用阿奇霉素（50-200mg/Kg）治疗的小鼠中只有25%在攻击中存活。我们的研究结果表明，与强力霉素-链霉素不同，阿奇霉素不能治愈实验性布鲁氏菌病。
