Hepple J, Robson P
Chilton Clinic, Warneford Hospital, Oxford, UK.
Addiction. 1996 Feb;91(2):269-73.
The responses of ex-smokers to an experimental cue exposure trial, and the effect of caffeine on these responses, were compared with those of a matched group of control subjects in a placebo controlled single-blind cross-over design. In contrast to placebo, caffeine protected the ex-smokers from a surge of anxiety and rise in blood pressure associated with exposure to smoking-related cues. Caffeine had no significant effects on the control group at this dose (equivalent to a single cup of strong coffee). The results are discussed with reference to Stewart's conditioned appetitive motivational model of addiction. It is suggested that further work may identify caffeine as an adjunct to smoking relapse prevention measures.
在一项安慰剂对照的单盲交叉设计中，将曾经吸烟者对实验性线索暴露试验的反应以及咖啡因对这些反应的影响，与一组匹配的对照受试者的反应进行了比较。与安慰剂不同，咖啡因可保护曾经吸烟者免受与接触吸烟相关线索有关的焦虑激增和血压升高的影响。在此剂量下（相当于一杯浓咖啡），咖啡因对对照组没有显著影响。参考斯图尔特的成瘾条件性食欲动机模型对结果进行了讨论。建议进一步的研究可能会确定咖啡因可作为吸烟复发预防措施的辅助手段。
