Ohara S, Tsurui M, Watanabe T, Ichikawa T, Hotta K
Department of Biochemistry, Kitasato University, Japan.
Pharmacol Toxicol. 1995 Dec;77(6):397-401. doi: 10.1111/j.1600-0773.1995.tb01049.x.
The present study was carried out to clarify the mechanism of histamine-induced gastric mucosal damage in rats. Following an injection of histamine (80 mg/kg), pH dropped within 30 min. and then recovered control value (pH = 4-5) 4 hr later. The decrease in mucosal mucin content and the appearance of haemorrhagic erosions followed the drop in pH. The recovery of mucosal mucin content preceded the healing of haemorrhagic erosions and pH recovery to the control level. Histamine also caused qualitative changes in corpus mucins. These qualitative changes induced by histamine were eliminated at 7 hr following the administration of histamine. It appears from the present results that increase in HCl and decrease in mucins induced by histamine bring about gastric damage.
本研究旨在阐明组胺诱导大鼠胃黏膜损伤的机制。注射组胺（80毫克/千克）后，pH值在30分钟内下降，4小时后恢复到对照值（pH = 4 - 5）。黏膜黏蛋白含量的降低和出血性糜烂的出现伴随着pH值的下降。黏膜黏蛋白含量的恢复先于出血性糜烂的愈合以及pH值恢复到对照水平。组胺还引起胃体黏蛋白的质的变化。组胺引起的这些质的变化在给予组胺7小时后消失。从目前的结果来看，组胺诱导的盐酸增加和黏蛋白减少导致胃损伤。
