Calore E E, Cavaliere M J, Perez N M, Takayasu V, Wakamatsu A, Kiss M H
Anatomia Patológica, Instituto de Infectologia Emílio Ribas, São Paulo, Brazil.
J Rheumatol. 1995 Dec;22(12):2246-9.
Systemic sclerosis (SSc) is characterized by abnormal deposition of collagen in the skin and by visceral involvement. Muscle weakness is a relatively frequent complication of SSc, although severity varies. We studied muscle pathology in patients with SSc with progressive muscle involvement.
We performed histochemical and immunohistochemical investigations to detect neural cell adhesion molecule (NCAM).
Five of the 6 cases of SSc expressed NCAM in atrophic angulated fibers (some fibers stained heavily with oxidative enzymes).
Neurogenic involvement in SSc is more frequent than reported.
系统性硬化症（SSc）的特征是皮肤中胶原蛋白异常沉积以及内脏受累。肌肉无力是SSc相对常见的并发症，尽管严重程度各不相同。我们研究了进行性肌肉受累的SSc患者的肌肉病理学。
我们进行了组织化学和免疫组织化学研究以检测神经细胞黏附分子（NCAM）。
6例SSc患者中有5例在萎缩的有角纤维中表达NCAM（一些纤维被氧化酶重度染色）。
SSc中的神经源性受累比报道的更为常见。
