Murakami C, Hino K, Okazaki M, Fujii K, Okuda M, Hanada H, Yamasaki T, Okita K
First Department of Internal Medicine, Yamaguchi University, School of Medicine, Ube.
Intern Med. 1996 Jun;35(6):468-71. doi: 10.2169/internalmedicine.35.468.
We describe a hepatitis B virus carrier who satisfied the criteria of autoimmune hepatitis proposed by the International Autoimmune Hepatitis Group. A 43-year-old Japanese female showed human leukocyte antigen typing including DR4 in addition to hypergammaglobulinemia, presence of autoantibodies, and liver histology suggestive of autoimmune hepatitis. Moreover, the predominant presence of hepatitis B core antigen in nuclei rather than in cytoplasm of hepatocytes suggested less of a possibility of liver cell damage related to hepatitis B virus infection. She completely responded to immunosuppressive therapy and no clinical or biochemical relapse has been recognized to date.
