Kraus P, Noack G
Institut für Pharmakologie und Toxikologie, Philipps Universität, Marburg, Germany.
J Enzyme Inhib. 1996;10(2):125-33. doi: 10.3109/14756369609020165.
10-100 mmol/l of acetate inhibits gamma-aminobutyric acid aminotransferase from rat brain mitochondria by 35-90%. Similarly, 50-100 mmol/l of chloride inhibits this enzyme by 10-30%. In either case, the inhibition is competitive with GABA and noncompetitive with alpha-ketoglutarate. The effect of sodium and potassium is negligible. gamma-Aminobutyric acid aminotransferase from rat liver mitochondria is also inhibited by acetate and chloride. The degree of inhibition of both hepatic and cerebral enzyme is nearly the same.
10至100毫摩尔/升的乙酸盐可使大鼠脑线粒体中的γ-氨基丁酸转氨酶活性抑制35%至90%。同样，50至100毫摩尔/升的氯化物可使该酶活性抑制10%至30%。在这两种情况下，抑制作用均与γ-氨基丁酸呈竞争性，与α-酮戊二酸呈非竞争性。钠和钾的影响可忽略不计。大鼠肝线粒体中的γ-氨基丁酸转氨酶也会受到乙酸盐和氯化物的抑制。肝酶和脑酶的抑制程度几乎相同。
