Effect of the antiallergic drug disodium cromoglycate on phosphodiesterase activity.
作者信息
Ochoa de Aspuru E, Zatón A M
机构信息
Department of Biochemistry and Molecular Biology, Faculty of Pharmacy, University of Basque Country, Vitoria-Gasteiz, Spain.
出版信息
J Enzyme Inhib. 1996;10(2):135-9. doi: 10.3109/14756369609020166.
PMID:8835938
Abstract
The antiallergic drug disodium cromoglycate and its non-antiallergic analogue dicoumarol, inhibit the enzymatic activity of phosphodiesterase with KI values of 0.8.10(-9) M and 1.6.10(-9) M, respectively. It seems that the dichromone group is responsible for this inhibition, independently of its antiallergic effect.
摘要
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