Jarrett A F, Armstrong A A, Alexander E
Department of Veterinary Pathology, Veterinary School, University of Glasgow, U.K.
Ann Oncol. 1996;7 Suppl 4:5-10. doi: 10.1093/annonc/7.suppl_4.s5.
The incidence of Hodgkin's disease shows marked heterogeneity with respect to age, gender, race, geographical locale, social class and histological subtype. The Epstein-Barr virus (EBV) is associated with a proportion of cases, approximately 40% in developed countries, and there is a body of evidence which suggests that mixed cellularity Hodgkin's disease is more likely to be EBV-associated than nodular sclerosis Hodgkin's disease. This study investigates the relationship between EBV and both age and histological subtype. We confirm the above subtype distribution and that childhood and older adult cases are more likely to be EBV-associated than young adult cases. Young adult nodular sclerosis cases are rarely EBV-associated providing further evidence that this is a separate disease entity. The results of this study support the multiple aetiology hypothesis which suggests that Hodgkin's disease in different age groups has different aetiologies. The epidemiology of Hodgkin's disease and studies investigating the distribution of EBV-associated cases are reviewed.
霍奇金淋巴瘤的发病率在年龄、性别、种族、地理位置、社会阶层和组织学亚型方面表现出显著的异质性。爱泼斯坦-巴尔病毒（EBV）与一定比例的病例相关，在发达国家约为40%，并且有大量证据表明混合细胞型霍奇金淋巴瘤比结节硬化型霍奇金淋巴瘤更可能与EBV相关。本研究调查了EBV与年龄和组织学亚型之间的关系。我们证实了上述亚型分布情况，并且儿童和老年病例比青年病例更可能与EBV相关。青年结节硬化型病例很少与EBV相关，这进一步证明这是一个独立的疾病实体。本研究结果支持多病因假说，该假说认为不同年龄组的霍奇金淋巴瘤有不同的病因。本文对霍奇金淋巴瘤的流行病学以及调查EBV相关病例分布的研究进行了综述。
