大鼠出生后发育过程中脑内谷胱甘肽水平的变化。

Changes in brain glutathione levels during postnatal development in the rat.

作者信息

Nanda D, Tolputt J, Collard K J

机构信息

Physiology Unit, School of Molecular and Medical Biosciences, University of Wales Cardiff, UK.

出版信息

Brain Res Dev Brain Res. 1996 Jul 20;94(2):238-41. doi: 10.1016/0165-3806(96)00061-2.

DOI:10.1016/0165-3806(96)00061-2

PMID:8836583

Abstract

The concentration of glutathione in the rat cerebral cortex, cerebellum and liver was examined during postnatal development. The glutathione level in both brain regions was low at the earliest age studied (postnatal day (PND) 3) and peaked at PND7. In the liver, the glutathione level was maximal at PND30. The glutathione peak at PND7 occurs during a period of intense synaptogenesis and may be related to a neuroprotective role during brain development.

摘要

在出生后的发育过程中，对大鼠大脑皮层、小脑和肝脏中的谷胱甘肽浓度进行了检测。在所研究的最早年龄（出生后第3天，PND 3）时，两个脑区的谷胱甘肽水平都很低，并在PND 7时达到峰值。在肝脏中，谷胱甘肽水平在PND 30时最高。PND 7时的谷胱甘肽峰值出现在一个强烈突触形成的时期，可能与大脑发育过程中的神经保护作用有关。