Benhaiem-Sigaux N, Ricolfi F, Keravel Y, Poirier J
Department of Pathology, Henri Mondor Hospital, Créteil, France.
Clin Neuropathol. 1996 Jul-Aug;15(4):231-3.
A 25-year-old woman presented with left progressive deafness due to an intracranial tumor of the cerebello-pontine angle. Biopsy and subsequent total surgical excision indicated origin from the acoustic nerve. Histologically, the tumor showed typical feature of Schwannoma associated with a population of epithelioid cells. Three years after surgery no local invasion, no relapse, and no metastasis were noted. Immunohistochemistry showed a strong positivity for S100 protein in the cytoplasm of Schwannian and epithelioid tumoral cell components. This positivity in the epithelioid cells correspond to a well differentiated cell population derived from a Schwann cell precursor explaining the benign course of the tumor. In the absence of similar cases of epithelioid Schwannoma of the acoustic nerve in literature, we will discuss the differential diagnosis, potential evolutivity, and origin of the epithelioid cells.
一名25岁女性因桥小脑角颅内肿瘤出现进行性左耳听力丧失。活检及随后的手术全切除显示肿瘤起源于听神经。组织学上，肿瘤表现为与一群上皮样细胞相关的神经鞘瘤典型特征。术后三年未发现局部侵犯、复发及转移。免疫组化显示施万细胞和上皮样肿瘤细胞成分的细胞质中S100蛋白呈强阳性。上皮样细胞中的这种阳性对应于源自施万细胞前体的高分化细胞群，解释了肿瘤的良性病程。鉴于文献中尚无类似的听神经上皮样神经鞘瘤病例，我们将讨论其鉴别诊断、潜在演变及上皮样细胞的起源。
