Franks A J
Histopathology. 1985 Dec;9(12):1339-50. doi: 10.1111/j.1365-2559.1985.tb02815.x.
A 50-year-old male presented with facial pain due to an extrinsic intracranial tumour involving pontine nerve roots. Biopsy and subsequent partial surgical excision indicated origin from the trigeminal nerve. Histologically the tumour had features of a neurilemmoma but in addition contained a population of epithelioid cells. Immunohistochemical studies demonstrated S100 protein in the non-epithelioid component but no reaction in the epithelioid cells, whilst vimentin was present in both cell types. Ultrastructurally the epithelioid cells showed features consistent with a Schwann cell nature and may represent a less well differentiated cell population derived from a Schwann cell precursor. The significance of these findings in relation to the cell of origin of neurilemmomas is discussed.
一名50岁男性因涉及脑桥神经根的颅外肿瘤而出现面部疼痛。活检及随后的部分手术切除显示肿瘤起源于三叉神经。组织学上，该肿瘤具有神经鞘瘤的特征，但此外还含有一群上皮样细胞。免疫组织化学研究表明，非上皮样成分中有S100蛋白，而上皮样细胞无反应，波形蛋白在两种细胞类型中均有表达。超微结构上，上皮样细胞表现出与施万细胞性质一致的特征，可能代表源自施万细胞前体的分化程度较低的细胞群体。讨论了这些发现与神经鞘瘤起源细胞的关系。
