Ulugöl A, Karadağ H C, Dökmeci D, Baldik Y, Dökmeci I
Department of Pharmacology, Faculty of Medicine, Trakya University, Edirne, Turkey.
Eur J Pharmacol. 1996 Jul 11;308(1):49-52. doi: 10.1016/0014-2999(96)00260-9.
Morphine is known to release histamine from mast cells and increase the turnover of neuronal histamine. It is also known that histamine receptors mediate some of the morphine effects. The contribution of histamine H1 and H2 receptors to the thermoregulatory effect of morphine in mice was investigated in the present experiments. Morphine produced a hypothermic effect, especially at the dose of 10 mg/kg. Although the histamine H1 receptor antagonist, dimethindene (0.1 mg/kg, i.p.), attenuated the hypothermic effect of morphine (10 mg/kg), a histamine H2 receptor antagonist, ranitidine (100 mg/kg, i.p.), had no effect. These results suggest that the hypothermic effect of morphine in mice is mediated, at least partly, through histamine H1 receptors.
众所周知，吗啡可从肥大细胞释放组胺并增加神经元组胺的更新率。还已知组胺受体介导吗啡的某些作用。在本实验中，研究了组胺H1和H2受体对吗啡在小鼠中的体温调节作用的贡献。吗啡产生了体温过低的效应，尤其是在剂量为10mg/kg时。尽管组胺H1受体拮抗剂二甲茚定（0.1mg/kg，腹腔注射）减弱了吗啡（10mg/kg）的体温过低效应，但组胺H2受体拮抗剂雷尼替丁（100mg/kg，腹腔注射）却没有作用。这些结果表明，吗啡在小鼠中的体温过低效应至少部分是通过组胺H1受体介导的。
