Carreño V, Quiroga J A
Hepatology Unit, Fundación Jiménez Diaz, Madrid, Spain.
J Hepatol. 1996;24(2 Suppl):74-6.
Therapies for chronic viral hepatitis B and C are aimed at clearing the virus and producing a sustained immunity. Manipulation of the biological response would confer an antiviral state and modulate the immune responses. For the development of new therapeutic agents against hepatitis viruses, reliable in vitro models are needed to study drug effects. Forthcoming therapies might combine natural or synthetic antiviral compounds and cytokines, together with novel approaches including anti-sense oligonucleotides and ribozymes.
慢性乙型和丙型病毒性肝炎的治疗旨在清除病毒并产生持续免疫力。对生物反应的调控将赋予抗病毒状态并调节免疫反应。为了开发抗肝炎病毒的新型治疗药物，需要可靠的体外模型来研究药物效果。未来的治疗方法可能会将天然或合成抗病毒化合物与细胞因子结合起来，同时采用包括反义寡核苷酸和核酶在内的新方法。
