Berggren T, Uvelius B
Department of Urology, Lund University Hospital, Sweden.
Scand J Urol Nephrol. 1996 Jun;30(3):179-84. doi: 10.3109/00365599609181296.
Mean and maximal micturition volumes following a standardized water intake were determined before and up to three days after unilateral pelvic ganglionectomy or sham operation in adult male rats. Sham operation did not change the volumes. Unilateral ganglionectomy on the other hand decreased significantly both mean and maximal micturition volumes (and thus increased micturition frequency). The effect was most pronounced 1 day after ganglionectomy, but was still significant after 3 days. Cystometrograms were recorded without and with atropine (1 mg/kg) before operation and 1, 2 or 3 days after sham-operation or ganglionectomy. Micturition pressure decreased to about 50% 1 day after ganglionectomy and remained at this level. Atropine decreased micturition pressure in the controls to about 55% of the initial. The atropine resistant pressure response in the ganglionectomized rats amounted to 90% after 1 day, and was still above 70% after 3 days. The sham-operated controls had no residual urine without or with atropine. The unilaterally ganglionectomized animals had no residual urine in the absence of atropine, but after administration of the drug the animals rapidly developed a significant residual urine.
在成年雄性大鼠中，测定了单侧盆腔神经节切除术或假手术后，标准化饮水后的平均排尿量和最大排尿量，测定时间为术前及术后三天内。假手术并未改变尿量。另一方面，单侧神经节切除术显著降低了平均排尿量和最大排尿量（从而增加了排尿频率）。这种影响在神经节切除术后1天最为明显，但在3天后仍很显著。在术前以及假手术或神经节切除术后1、2或3天，分别记录了无阿托品（1 mg/kg）和有阿托品时的膀胱测压图。神经节切除术后1天，排尿压力降至约50%，并维持在该水平。阿托品使对照组的排尿压力降至初始值的约55%。神经节切除术后大鼠对阿托品的抗性压力反应在1天后达到90%，3天后仍高于70%。假手术对照组无论有无阿托品均无残余尿。单侧神经节切除的动物在无阿托品时无残余尿，但给药后动物迅速出现显著的残余尿。
