Bernard D, Gouault-Heilmann M, Ansquer J C, Levent M, Ladieu D, Lagrue G
Ann Med Interne (Paris). 1977 Apr;128(4):325-33.
Thrombo-embolic accidents are extremely common during nephrotic syndrome (8 p. 100). They share the garvity of thrombo-embolic accidents occurring under other circumstances (20 p. 100 mortality). They are accompanied by numerous disturbances in clotting factors the mechanisms of which are discussed. Nevertheless the study of these disturbances does not make it possible to predict the onset of a thrombo-embolic problem. By contrast, the degree of hypoalbuminaemia is significantly correlated with the thrombotic risk (p. 0.001) and serves as an indication for the necessity of preventive heparin therapy, in the form of calcium heparinate. In this way the authors have been successful in eliminating the thrombo-embolic risk in association with nephrotic syndrome.
血栓栓塞事件在肾病综合征期间极为常见（每100例中有8例）。它们与在其他情况下发生的血栓栓塞事件的严重性相当（死亡率为每100例中有20例）。它们伴有许多凝血因子紊乱，其机制将予以讨论。然而，对这些紊乱的研究并不能预测血栓栓塞问题的发生。相比之下，低白蛋白血症的程度与血栓形成风险显著相关（p = 0.001），并作为以肝素钙形式进行预防性肝素治疗必要性的指标。通过这种方式，作者成功消除了与肾病综合征相关的血栓栓塞风险。
