Branson H E, Vaziri N D, Slater L M
J Natl Med Assoc. 1982 Apr;74(4):339-43.
Analysis of tests of coagulation and fibrinolysis from 20 adult nephrotics prior to the onset of therapy disclosed that 40 percent had low factor XII levels. The mean factor XI was normal. The platelet count and fibrinogen concentration were elevated. The findings of this study on adults are similar to those of Honig and Lindley(21) in the nephrotic syndrome of childhood. Subjects with minimal change disease constituted a small (15 percent) but readily segregated subpopulation without evidence of fibrinolysis in association with low factor XII activity. Prolongation of the activated partial thromboplastin time corresponded in every instance with factor XII activities of ≤30 percent. Lengthening of the one stage prothrombin time was not directly attributable to factor deficiencies.
对20名成年肾病患者治疗开始前的凝血和纤维蛋白溶解试验分析表明，40%的患者因子Ⅻ水平较低。因子Ⅺ平均水平正常。血小板计数和纤维蛋白原浓度升高。这项针对成年人的研究结果与霍尼格和林德利（21）对儿童肾病综合征的研究结果相似。微小病变病患者构成了一个较小（15%）但易于区分的亚群，没有纤维蛋白溶解与低因子Ⅻ活性相关的证据。活化部分凝血活酶时间延长在每种情况下都与因子Ⅻ活性≤30%相对应。一期凝血酶原时间延长并非直接归因于因子缺乏。
