Gómez M, Curiel G, Mendez J, Rodriguez M, Moneo I
Servicio de Alergia, Clínica Puerta de Hierro, Madrid, Spain.
Allergy. 1996 Jun;51(6):425-9. doi: 10.1111/j.1398-9995.1996.tb04642.x.
This study deals with a 34-year-old female cook with no previous history of atopy, who was studied because of allergic rhinoconjunctivitis and contact urticaria in both hands associated with severe itching when she handled raw carrot. The patient had had anaphylactic episodes after accidental ingestion of raw carrots, but she tolerated cooked carrots. Skin prick tests with carrot, celery, and olive, and birch, grass, and mugwort pollens were positive. Total IgE was 411 UI/ml. Specific IgE to olive, grass, and weed pollens were 10.92, 6.17, and 2.4 AU/ml, respectively. The histamine release test was positive for carrot, celery, celeriac, and olive pollen up to a dilution of 1/10(6). Immunoblot of raw carrot showed a single IgE-binding 18-kDa band. IgE reactivity for raw carrot immunoblot was completely inhibited by carrot and by celery, but not by olive or grass pollens. Specific IgE to olive pollen was not inhibited by carrot. The existence of monosensitization to an 18-kDa protein in carrot and specific IgE to olive pollen has not been reported in the celery-carrot-mugwort-spice syndrome.
本研究涉及一名34岁的女性厨师，她既往无特应性病史，因过敏性鼻结膜炎以及双手接触荨麻疹伴处理生胡萝卜时严重瘙痒而接受研究。该患者在意外摄入生胡萝卜后曾发生过敏反应，但能耐受熟胡萝卜。对胡萝卜、芹菜、橄榄以及桦树、草和艾蒿花粉进行的皮肤点刺试验呈阳性。总IgE为411 UI/ml。对橄榄、草和杂草花粉的特异性IgE分别为10.92、6.17和2.4 AU/ml。组胺释放试验对胡萝卜、芹菜、块根芹和橄榄花粉呈阳性，最高稀释度达1/10(6)。生胡萝卜的免疫印迹显示一条单一的18-kDa IgE结合带。生胡萝卜免疫印迹的IgE反应性被胡萝卜和芹菜完全抑制，但未被橄榄或草花粉抑制。胡萝卜对橄榄花粉的特异性IgE未被抑制。在芹菜-胡萝卜-艾蒿-香料综合征中，尚未报道对胡萝卜中一种18-kDa蛋白的单一致敏以及对橄榄花粉的特异性IgE的存在。
