Plaksina A N, Plaksin A I
Antibiotiki. 1977 Apr;22(4):340-4.
The effect of subsequent cyclic administration of oleandomycin and tetracycline on the titer of the complement, the content of lysozyme, the bactericidal properties of the serum and the presence of the antibiotic specific antibodies in the blood serum found in the Hoigne reaction were studied on rabbits. It was found that the subsequent cyclic administration of the antibiotics to both the intact animals and the animals with experimental staphylococcal sepsis was accompanied by an increase in the titer of the complement only on the 7th day of administration of oleandomycin, the first antibiotic. The subsequent administration of tetracycline and especially discontinuation of the antibiotics use resulted in a significant, stable and prolonged decrease in the complement titer. The cyclic subsequent administration of oleandomycin and tetracycline for 7 days was accompanied by an increase in the lysozyme content and serum bactericidal properties. Changes in the factors of non-specific resistance under the effect of the subsequent cyclic administration of oleandomycin and tetracycline on both the intact animals and the animals with experimental staphylococcal sepsis were accompanied by an appearance, progressive increase and prolonged preservation in the serum of the antibiotic specific antibodies found in the Hoigne reaction. A possibility of producing specific antibodies simultaneously to the 2 antibiotics, i. e. oleandomycin and tetracycline in their administration in subsequent 7-day cycles was shown.
在兔子身上研究了随后循环给予竹桃霉素和四环素对补体滴度、溶菌酶含量、血清杀菌特性以及血清中霍伊内反应中发现的抗生素特异性抗体的影响。结果发现，对完整动物和患有实验性葡萄球菌败血症的动物随后循环给予抗生素时，仅在第一种抗生素竹桃霉素给药的第7天补体滴度升高。随后给予四环素，尤其是停止使用抗生素后，补体滴度出现显著、稳定且持续时间长的下降。循环连续7天给予竹桃霉素和四环素会伴随着溶菌酶含量和血清杀菌特性的增加。在完整动物和患有实验性葡萄球菌败血症的动物中，随后循环给予竹桃霉素和四环素对非特异性抵抗力因素的影响伴随着血清中霍伊内反应中发现的抗生素特异性抗体的出现、逐渐增加和长期保存。研究表明，在随后7天的给药周期中同时给予两种抗生素（即竹桃霉素和四环素）时有可能产生特异性抗体。
