Tone J, Shioji S, Kondo T, Kawakami M, Mitsuhashi S
Jpn J Antibiot. 1976 May;29(5):571-9.
The combination effect of tetracycline (TC) and oleandomycin (OM) on acute infection of mice with four strains of Staphylococcus aureus including TC or OM resistant ones was examined by the quantitative determination of protective potencies of single and combined drugs. The grade of synergism was expressed by the synergistic ratio (SR), a ratio of experimentally determined potency of the combined drug over a hypothetical potency in which additive effect of the both drugs is assumed. With 3 out of the 4 strains of S. aureus synergism between TC and OM or triacetyloleandomycin (TAO) was demonstrated by the determination of the 50% effective dose and by statistical examination of the SR. The grade of synergistic protection by these drugs varied with the strains infected and it did not depend upon the sensitivity to antibiotics or grade of synergism in vitro. There was no synergistic enhancement of acute toxic action in the combined administration of TC and OM to mice.
通过定量测定单一药物和联合药物的保护效力，研究了四环素（TC）和竹桃霉素（OM）对包括耐TC或耐OM菌株在内的四株金黄色葡萄球菌急性感染小鼠的联合效应。协同程度用协同比（SR）表示，即联合药物的实验测定效力与假设两种药物具有相加效应时的效力之比。通过测定50%有效剂量和对SR进行统计学检验，证明了在4株金黄色葡萄球菌中的3株中，TC与OM或三乙酰竹桃霉素（TAO）之间存在协同作用。这些药物的协同保护程度因感染菌株而异，且不取决于对抗生素的敏感性或体外协同程度。TC和OM联合给药对小鼠的急性毒性作用没有协同增强。
