Gray W L, Gusick N J, Ek-Kommonen C, Kempson S E, Fletcher T M
Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock 72205, USA.
Virus Res. 1995 Dec;39(2-3):181-93. doi: 10.1016/0168-1702(95)00091-7.
Simian varicella virus (SVV) causes a varicella-like disease in nonhuman primates. The DNA sequence and genetic organization of the inverted repeat region (RS) of the SVV genome was determined. The SVV RS is 7559 bp in size with 56% guanine+cytosine (G+C) content and includes 3 open reading frames (ORFs). The SVV RS1 ORF encodes a 1279 amino acid (aa) protein with 58 and 39% identity to the varicella-zoster virus (VZV) gene 62 and herpes simplex virus type 1 (HSV-1) ICP4 homologs, respectively. The predicted 261 aa SVV RS2 polypeptide possesses 52% identity with the VZV gene 63 homolog and 23% identity with the HSV-1 ICP22. The SVV RS3 encodes a 187 aa polypeptide with 56% and 28% identity to the VZV gene 64 and the HSV-1 US10 homologs, respectively, and includes an atypical zinc finger motif. A G+C-rich 16 base-pair (bp) sequence which is repeated 7 times and a putative SVV origin of replication were identified between the RS1 and RS2 ORFs. Comparison with the VZV RS indicates the SVV and VZV RS regions are similar in size and genetic organization.
猿猴水痘病毒（SVV）可在非人灵长类动物中引发类似水痘的疾病。测定了SVV基因组反向重复区域（RS）的DNA序列和基因组织。SVV的RS大小为7559 bp，鸟嘌呤+胞嘧啶（G+C）含量为56%，包含3个开放阅读框（ORF）。SVV的RS1 ORF编码一种1279个氨基酸（aa）的蛋白质，分别与水痘-带状疱疹病毒（VZV）基因62和单纯疱疹病毒1型（HSV-1）ICP4同源物具有58%和39%的同一性。预测的261个aa的SVV RS2多肽与VZV基因63同源物具有52%的同一性，与HSV-1 ICP22具有23%的同一性。SVV的RS3编码一种187个aa的多肽，分别与VZV基因64和HSV-1 US10同源物具有56%和28%的同一性，并包含一个非典型锌指基序。在RS1和RS2 ORF之间鉴定出一个富含G+C的16碱基对（bp）序列，该序列重复7次以及一个推测的SVV复制起点。与VZV的RS比较表明，SVV和VZV的RS区域在大小和基因组织上相似。
