Popova G O, Vinidchenko N N, Mikhalevich R V, Sokolova M T, Makarovskaia L N
Antibiotiki. 1977 Apr;22(4):348-53.
The effect of various antibiotics, such as streptomycin, gentamicin, ampicillin, benzylpenicillin, tetracycline, chlortetracycline and levomycetin on the plague bacteria (strain Y. pestis EV) located inside the cells was studied. Peritoneal macrophages of albino mice with aceptic inflammation of the abdominal cavity caused by intraperitoneal administration of 2 ml of sterile meat-peptone broth were used in the experiments. The ratio of the macrophages and microbes was 1 : 50. A part of the mice were treated with prodigiozan 24 hours before taking the exudate. The preparations of the macrophages of albino mice with the microbes absorbed by them served as the control. The effect of the antibiotics and their combinations with prodigiozan was stimated by the coefficient of multiplication suppression against the control. The observations were made in dynamics. The studies showed that the macrophage activity of the mice treated with prodigiozan after exposure to the antibiotics was reliably higher than that in the control and digestion of the microbes located inside the cells started earlier, providing more complete phagocytosis.
研究了链霉素、庆大霉素、氨苄青霉素、苄青霉素、四环素、金霉素和氯霉素等多种抗生素对细胞内鼠疫杆菌（鼠疫耶尔森菌EV株）的作用。实验使用了经腹腔注射2ml无菌肉蛋白胨肉汤导致腹腔无菌性炎症的白化小鼠的腹腔巨噬细胞。巨噬细胞与微生物的比例为1:50。一部分小鼠在采集渗出液前24小时用灵菌红素处理。以吸收了微生物的白化小鼠巨噬细胞制剂作为对照。通过与对照相比的增殖抑制系数来评估抗生素及其与灵菌红素组合的效果。进行了动态观察。研究表明，在接触抗生素后用灵菌红素处理的小鼠的巨噬细胞活性确实高于对照，细胞内微生物的消化开始得更早，从而实现更完全的吞噬作用。
