Moore C, Lewis D, Becker J, Leikin J
United States Drug Testing Laboratories Inc., Chicago, IL 60612, USA.
J Anal Toxicol. 1996 Jan-Feb;20(1):50-1. doi: 10.1093/jat/20.1.50.
The determination of 11-nor-delta 9-tetrahydrocannabinol-9-carboxylic acid (THCCOOH), the major urinary metabolite of delta 9-tetrahydrocannabinol (THC), in meconium is extremely difficult because of the high concentration of lipids in the specimen and the low concentration of drug present. A simple, robust, analytical procedure for the screening and confirmation of THCCOOH in meconium is presented. To our knowledge, the procedure is the first published method for the successful confirmation of THCCOOH in meconium and is used routinely in our laboratory for the purpose of detecting marijuana use during pregnancy.
由于胎粪样本中脂质浓度高且药物含量低，要测定9-四氢大麻酚（THC）的主要尿液代谢物11-去甲-Δ9-四氢大麻酚-9-羧酸（THCCOOH）极为困难。本文介绍了一种简单、可靠的分析方法，用于筛查和确证胎粪中的THCCOOH。据我们所知，该方法是首次发表的成功确证胎粪中THCCOOH的方法，并且在我们实验室中常规用于检测孕期是否使用大麻。
