Hellgren L, Larsson K, Vincent J
Arch Dermatol Res (1975). 1977 May 27;258(3):295-303. doi: 10.1007/BF00561133.
Thermal effects were achieved from skin biopsies (epidermis, corium, subcutis) measured by batch-microcalorimetry, after exposure to potent inflammatory or antiinflammatory substances (compound 48/80, histamine, serotonine and hydrocortisone phosphate). Exothermic effects were achieved from 48-80, histamine and hydrocortisone phosphate, when exposed to the skin and lasting for varying time. From serotonine initial endothermic signals were achieved but after about 50 min there was stabilizing of the thermal reaction at the baseline. To analyze the nature of these non-specific thermal effects, determinations of O2 consumption and CO2 production were performed, using Warburg technique on exactly matched tissue pieces exposed to the same substances and run parallely with the microcalorimetrical determinations. An increased respiration, probably as an indicator of increased metabolism was registrated for all test substances acting on the skin. It felt, that the thermal effects reflect an increased metabolism of the tissue exposed to the test substances.
通过批量微量量热法测量皮肤活检组织（表皮、真皮、皮下组织）在暴露于强效炎症或抗炎物质（化合物48/80、组胺、血清素和磷酸氢化可的松）后的热效应。当暴露于皮肤并持续不同时间时，化合物48/80、组胺和磷酸氢化可的松产生放热效应。血清素最初产生吸热信号，但约50分钟后热反应在基线处稳定下来。为了分析这些非特异性热效应的性质，使用瓦氏技术对暴露于相同物质的完全匹配的组织切片进行氧气消耗和二氧化碳产生的测定，并与微量量热测定平行进行。对于所有作用于皮肤的测试物质，均记录到呼吸增加，这可能是代谢增加的指标。感觉热效应反映了暴露于测试物质的组织代谢增加。
