Ronco J J, Fenwick J C, Tweeddale M G
Department of Medicine, Vancouver Hospital and Health Sciences Centre, University of British Columbia, Canada.
Crit Care Clin. 1996 Jul;12(3):645-59. doi: 10.1016/s0749-0704(05)70268-2.
The strategy of treating critically ill patients by increasing oxygen delivery and consumption to values previously observed among survivors of critical illness (supranormal values) is based on the belief that (1) tissue hypoxia may persist in critically ill patients despite aggressive early resuscitation to traditional endpoints of adequate tissue perfusion and (2) that increasing oxygen delivery can reverse tissue hypoxia. This article addresses the question of whether increasing oxygen delivery improves outcomes in critically ill patients by reviewing the relationship between whole-body oxygen delivery and consumption and by critically examining the randomized controlled trials that have increased oxygen delivery to supranormal values.
通过将氧输送和氧消耗增加到危重病幸存者先前观察到的值（超常值）来治疗危重病患者的策略基于以下信念：（1）尽管对传统的充分组织灌注终点进行了积极的早期复苏，但危重病患者可能仍存在组织缺氧；（2）增加氧输送可逆转组织缺氧。本文通过回顾全身氧输送与氧消耗之间的关系，并严格审查将氧输送增加到超常值的随机对照试验，探讨增加氧输送是否能改善危重病患者的预后这一问题。
