Schmidt B, Schimpl G, Höllwarth M E
Department of Paediatric Surgery, University of Graz, Medical School, Austria.
Eur J Pediatr. 1996 Aug;155(8):649-52. doi: 10.1007/BF01957145.
Between April 1988 and July 1995, 11 children with lymphangioma were treated with intralesional OK-432 injection. In 7 patients it was the primary therapy and total shrinkage of the lesion was obtained in 5 of them. Two patients did not respond and the children underwent surgery. Following incomplete surgical removal or recurrence of the lymphangioma, intralesional OK-432 injection was used as secondary therapy in 4 patients. Total regression was observed in 2 cases and marked regression in the 2 others. No serious side-effects except fever lasting for 2-3 days and slight tenderness with swelling of the lymphangioma for 3-4 days after the injection was noted. Local inflammatory reaction did not cause any damage to the overlying skin and did not lead to scar formation. Depending on the size, location, and anatomical relationship of the airway, intralesional injections of the lymphangiomas were performed under general anaesthesia and the children were observed for 24 h. There was no recurrence after follow up periods ranging from 2 months to 7 years.
Intralesional injection OK-432 represents an alternative, safe and effective treatment for lymphangiomas. It can be used as the primary therapy, after partial surgical excision, or in recurrent lymphangiomas.
1988年4月至1995年7月期间，11例淋巴管瘤患儿接受了瘤内注射OK-432治疗。其中7例为初次治疗，5例病变完全消退。2例无反应，患儿接受了手术。在淋巴管瘤手术切除不完全或复发后，4例患儿接受瘤内注射OK-432作为二次治疗。2例完全消退，另2例明显消退。除注射后持续2 - 3天的发热及淋巴管瘤肿胀伴轻度压痛3 - 4天外，未观察到严重副作用。局部炎症反应未对覆盖皮肤造成任何损伤，也未导致瘢痕形成。根据气道的大小、位置及解剖关系，在全身麻醉下对淋巴管瘤进行瘤内注射，并对患儿观察24小时。随访2个月至7年期间无复发。
瘤内注射OK-432是一种治疗淋巴管瘤的安全、有效的替代方法。它可作为初次治疗、部分手术切除后或复发性淋巴管瘤的治疗方法。
