Chong S A, Choo H L
Institute of Mental Health, Singapore.
Aust N Z J Psychiatry. 1996 Jun;30(3):350-3. doi: 10.3109/00048679609064998.
This study aimed to determine the prevalence of smoking among Chinese with schizophrenia, and to determine if smokers and nonsmokers differ in their age of onset of illness and neuroleptic requirement.
One hundred and ninety-five patients were assessed by a single rater using the Brief Psychiatric Rating Scale (BPRS) and the Simpson-Angus Scale. Other historical, demographic and treatment variables were recorded from case records and interviews with patients and family members.
A higher rate of smoking was found in patients with schizophrenia than in the general population. There was no significant difference between the smokers and non-smokers in their respective neuroleptic dosages and extrapyramidal side-effects but the smokers had a significantly higher BPRS score.
Racial difference is proposed to account for this discrepancy from other Western studies. The contribution of nicotine towards aggravating schizophrenic symptoms is also considered.
本研究旨在确定中国精神分裂症患者中的吸烟率,并确定吸烟者与非吸烟者在发病年龄和抗精神病药物需求方面是否存在差异。
由一名评估者使用简明精神病评定量表(BPRS)和辛普森-安格斯量表对195名患者进行评估。从病例记录以及对患者和家属的访谈中记录其他病史、人口统计学和治疗变量。
发现精神分裂症患者的吸烟率高于一般人群。吸烟者和非吸烟者在各自的抗精神病药物剂量和锥体外系副作用方面没有显著差异,但吸烟者的BPRS评分显著更高。
种族差异被认为是造成与其他西方研究结果存在差异的原因。同时也考虑了尼古丁对加重精神分裂症症状的作用。