Liao Ding-Liao, Yang Jen-Yi, Lee Shin-Min, Chen Hong, Tsai Shih-Jen
Department of Psychiatry, Pali Psychiatric Hospital, Central Taiwan Office, Department of Health, Taipei, Taiwan, ROC.
Neuropsychobiology. 2002;45(4):172-5. doi: 10.1159/000063666.
This study investigated the prevalence of smoking and its association with the clinical characteristics of Chinese inpatients with chronic schizophrenia.
Schizophrenic patients hospitalized in chronic wards were assessed using Brief Psychiatric Rating Scale (BPRS), Abnormal Involuntary Movements Scale (AIMS) and Folstein Mini-Mental Status Examination (MMSE) testing.
Of 257 patients, 105 smoked and 4 had ceased. Males exhibited a higher prevalence of smoking than females (p < 0.001). Smoking was not significantly associated with age at onset (AAO), chlorpromazine equivalents, MMSE, AIMS, BPRS positive symptom subscale, BPRS negative symptom subscale or total BPRS scores. Smokers had higher BPRS general subscales.
Compared to the general population, smoking prevalence was slightly higher in schizophrenic males, double in schizophrenic females, but no difference in refractory schizophrenic clozapine users. Smoking did not affect patient AAO or daily antipsychotic dose. Patients with a higher BPRS general subscale may smoke to relieve affective symptoms.
本研究调查了中国慢性精神分裂症住院患者的吸烟率及其与临床特征的关联。
使用简明精神病评定量表（BPRS）、异常不自主运动量表（AIMS）和福斯丁简易精神状态检查表（MMSE）对在慢性病房住院的精神分裂症患者进行评估。
257例患者中，105例吸烟，4例已戒烟。男性吸烟率高于女性（p<0.001）。吸烟与起病年龄（AAO）、氯丙嗪等效剂量、MMSE、AIMS、BPRS阳性症状分量表、BPRS阴性症状分量表或BPRS总分无显著关联。吸烟者的BPRS一般分量表得分较高。
与普通人群相比，精神分裂症男性的吸烟率略高，精神分裂症女性的吸烟率则翻倍，但难治性精神分裂症氯氮平使用者无差异。吸烟不影响患者的起病年龄或每日抗精神病药物剂量。BPRS一般分量表得分较高的患者可能通过吸烟来缓解情感症状。
