Chaung H M, Hong C H, Chiang C P, Lin S K, Kuo Y S, Lan W H, Hsieh C C
School of Dentistry, College of Medicine, National Taiwan University, Taipei, ROC.
J Formos Med Assoc. 1996 Jul;95(7):545-50.
Calcium phosphate cement (CPC) and pure calcium hydroxide were used as direct pulp-capping agents on the deliberately exposed pulp tissue of 60 teeth in five monkeys. Their effects on the pulp tissue of individual teeth were observed and histologically compared after 12, 20 and 24 weeks. The results showed that both materials produced similar responses with regard to their biocompatibility and induction of hard tissue barrier formation. Vasodilatation, chronic inflammation and calcification nidi scattered within the pulp tissue of the 12-week group were observed. Twenty weeks after application of capping materials, a crude reparative dentinal bridge with inclusion of soft tissue or bulky capping agents appeared. A more mature, hard tissue barrier with a better degree of mineralization and formation of dentinal tubules was demonstrated in the 24-week group. The above findings associated with the abilities of self-setting and fair compressive strength suggest that CPC appears superior to pure calcium hydroxide and may have potential for clinical application, although many issues remain to be further investigated.
磷酸钙骨水泥（CPC）和纯氢氧化钙被用作直接盖髓剂，应用于5只猴子的60颗牙齿故意暴露的牙髓组织上。在12周、20周和24周后观察它们对单颗牙齿牙髓组织的影响，并进行组织学比较。结果表明，两种材料在生物相容性和诱导硬组织屏障形成方面产生了相似的反应。在12周组的牙髓组织中观察到血管扩张、慢性炎症和散在的钙化灶。应用盖髓材料20周后，出现了包含软组织或大量盖髓剂的粗糙修复性牙本质桥。在24周组中显示出矿化程度更好且有牙本质小管形成的更成熟的硬组织屏障。上述与自凝能力和良好抗压强度相关的发现表明，尽管仍有许多问题有待进一步研究，但磷酸钙骨水泥似乎优于纯氢氧化钙，可能具有临床应用潜力。
