Weller A, Gispan I H, Smith G P
Department of Psychology, Bar Ilan University, Ramat Gan, Israel.
Physiol Behav. 1996 Aug;60(2):361-4.
The postingestive inhibitory control of independent ingestion produced by gastric preloads was investigated in 12-day-old Sprague-Dawley rats. Pups received isovolumetric (5% of body weight) preloads of saline (0.9%), glucose (5%, 10%, or 20%) or maltose (5%, 10%, or 20%) 5 min before a 30-min independent ingestion test in which pups licked milk from the floor of the test chamber. All preloads reduced intake significantly compared to the control condition in which pups were intubated, but no preload was administered. The reduction of intake produced by the isovolumetric, isotonic solutions (saline, 5% glucose, and 10% maltose) is consistent with the stimulation of a preabsorptive, inhibitory mechanism sensitive to volume. The significantly larger reduction of intake produced by isovolumetric, hypertonic solutions (20% glucose and 20% maltose) is consistent with the stimulation of an additional postingestive inhibitory mechanism sensitive to the osmotic, saccharidic, or, in the case of 20% glucose, metabolic properties of these solutions. Because preloads were given 5 min prior to the intake tests, it is likely that the site of action of both inhibitory mechanisms was preabsorptive, although a postabsorptive site for part of the inhibitory effect of 20% glucose cannot be excluded.
在12日龄的斯普拉格-道利大鼠中研究了胃预负荷对自主摄食产生的餐后抑制控制。在30分钟的自主摄食试验前5分钟，幼崽接受等体积（体重的5%）的生理盐水（0.9%）、葡萄糖（5%、10%或20%）或麦芽糖（5%、10%或20%）预负荷，在该试验中幼崽从测试室地板舔食牛奶。与未给予预负荷但插管的对照情况相比，所有预负荷均显著减少了摄入量。等体积、等渗溶液（生理盐水、5%葡萄糖和10%麦芽糖）产生的摄入量减少与对体积敏感的吸收前抑制机制的刺激一致。等体积、高渗溶液（20%葡萄糖和20%麦芽糖）产生的摄入量显著更大减少与对这些溶液的渗透压、糖类或（对于20%葡萄糖而言）代谢特性敏感的额外餐后抑制机制的刺激一致。由于在摄入试验前5分钟给予预负荷，两种抑制机制的作用部位很可能是吸收前的，尽管不能排除20%葡萄糖部分抑制作用的吸收后部位。
