Weller A, Gispan I H, Armony-Sivan R, Ritter R C, Smith G P
Department of Psychology, Bar Ilan University, Ramat Gan, Israel.
Physiol Behav. 1997 Oct;62(4):871-4. doi: 10.1016/s0031-9384(97)00256-4.
The ontogenetic development of postingestive inhibitory control of ingestion by an oil preload was examined in preweaning rats. Gastric preloads (5% b.wt) of water, mineral oil or corn oil were administered 5 min before a 30-min intake test in which pups licked milk from the floor of a test chamber. Preloads of corn oil decreased intake significantly compared with preloads of mineral oil or water on Postnatal Days 15 and 18, but not on Postnatal Day 12. Because preloads of corn oil reduced intake ore than preloads of mineral oil, it is possible that the inhibitory effect of corn oil is due to its fats rather than to its oily texture. Cholecystokinin (CCK), presumably released from the small intestine, apparently mediates part of this inhibitory effect because pretreatment with devazepide, a specific CKKA antagonist, significantly reduced the inhibition produced by corn oil.
在断奶前的大鼠中研究了油预负荷对摄食的餐后抑制控制的个体发育。在30分钟的摄食测试前5分钟，给予胃预负荷（体重的5%）的水、矿物油或玉米油，在测试中幼崽从测试室的地板上舔食牛奶。与矿物油或水的预负荷相比，玉米油预负荷在出生后第15天和第18天显著降低了摄入量，但在出生后第12天没有。由于玉米油预负荷比矿物油预负荷减少的摄入量更多，因此玉米油的抑制作用可能是由于其脂肪而不是其油性质地。胆囊收缩素（CCK）可能从小肠释放，显然介导了这种抑制作用的一部分，因为用特异性CCK A拮抗剂地伐西匹预处理可显著降低玉米油产生的抑制作用。
