Sclafani A, Lucas F
Department of Psychology, Brooklyn College and the Graduate School, City University of New York, Brooklyn 11210, USA.
Physiol Behav. 1996 Aug;60(2):447-53. doi: 10.1016/s0031-9384(96)80018-7.
The effects of abdominal vagotomy on the flavor preferences conditioned by Polycose (a maltodextrin) were investigated in female rats. Using an oral-delay training method, a modest conditioned flavor preference (67%) was obtained in control rats but not in rats with subtotal abdominal vagotomy (hepatic branch intact). The rats were fed a chow diet, and gastric stasis in the vagotomized rats may have interfered with preference learning. To facilitate conditioning, the rats were switched to a liquid maintenance diet and trained with new flavors paired with intragastric (IG) infusions of Polycose and water. With this procedure, the vagotomized and control rats acquired strong preferences (83-88%) for the flavor paired with IG Polycose. In a second experiment, flavor preferences conditioned by IG Polycose were obtained in rats with total abdominal vagotomy although the preference was attenuated relative to control rats (79% vs. 97%). Gastric motor problems (dumping) may have been a factor because the vagotomized rats consumed much less flavored solution (and therefore received less IG Polycose) during training than did controls. These findings indicate that an intact vagus nerve is not necessary to obtain carbohydrate-conditioned preferences, although vagotomy may interfere with the conditioning in some experimental situations.
研究了腹部迷走神经切断术对雌性大鼠由聚葡萄糖（一种麦芽糊精）诱导的口味偏好的影响。采用口服延迟训练方法，对照大鼠获得了适度的条件性口味偏好（67%），但腹部迷走神经次全切断（肝支完整）的大鼠未获得。大鼠食用普通饲料，迷走神经切断术大鼠的胃淤滞可能干扰了偏好学习。为便于进行条件训练，将大鼠改为液体维持饲料，并使用与聚葡萄糖和水的胃内（IG）输注配对的新口味进行训练。通过该程序，迷走神经切断术大鼠和对照大鼠对与IG聚葡萄糖配对的口味产生了强烈的偏好（83 - 88%）。在第二个实验中，腹部迷走神经完全切断的大鼠获得了由IG聚葡萄糖诱导的口味偏好，尽管相对于对照大鼠，该偏好有所减弱（79%对97%）。胃运动问题（倾倒）可能是一个因素，因为在训练期间，迷走神经切断术大鼠比对照大鼠消耗的调味溶液少得多（因此接受的IG聚葡萄糖也少得多）。这些发现表明，完整的迷走神经对于获得碳水化合物诱导的偏好并非必要，尽管在某些实验情况下，迷走神经切断术可能会干扰条件训练。
