Natelson B H, Ottenweller J E, Tapp W N, Bergen M, Soldan S
Neurobehavioral Unit, VA Medical Center, East Orange, NJ 07018-1095, USA.
Physiol Behav. 1996 Aug;60(2):463-8. doi: 10.1016/s0031-9384(96)80020-5.
In previous experiments we have shown that hamsters with inherited heart disease--cardiomyopathic hamsters (CMHs)--live longer if they spend their lives in an environment devoid of time cues. The purpose of this experiment was to test the several hypotheses by which life in constant light could extend life in CMHs. To do this, CMHs were allowed to spend their lives in one of six different lighting conditions: constant light, LD 12:12, LD 23:1, LD 1:23, LD 1:23.2, and LD 1:23.6. The only schedule to produce a significant extension of life was LD 1:23.6; in contrast to LD 1:23.2, this schedule is photostimulatory. Of the hypotheses tested to evaluate the life-enhancing effects of constant light, support was found for only the one stating that non-24-h LD regimens are health enhancing. Although some evidence was found relating testicular size to life span, dissociations between these variables indicate that testicular function does not play an overriding role in modulating the phototherapeutic effects.
在先前的实验中我们已经表明，患有遗传性心脏病的仓鼠——心肌病仓鼠（CMH）——如果在没有时间线索的环境中生活，寿命会更长。本实验的目的是检验几个假说，即持续光照环境下的生活会延长CMH的寿命。为此，让CMH在六种不同光照条件之一的环境中生活：持续光照、12小时光照/12小时黑暗（LD 12:12）、23小时光照/1小时黑暗（LD 23:1）、1小时光照/23小时黑暗（LD 1:23）、1小时光照/23.2小时黑暗（LD 1:23.2）以及1小时光照/23.6小时黑暗（LD 1:23.6）。唯一能显著延长寿命的光照时间表是LD 1:23.6；与LD 1:23.2相比，这个时间表具有光刺激作用。在为评估持续光照对寿命延长作用而检验的假说中，仅发现支持“非24小时的光照/黑暗方案有益健康”这一假说的证据。虽然发现了一些睾丸大小与寿命之间的关联，但这些变量之间的分离表明，睾丸功能在调节光疗效果方面并不起主导作用。
