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8-Methylguanine-containing oligonucleotides: useful structural constraint for Z form DNA.

作者信息

Kawai K, Sugiyama H, Fujimoto K, Saito I

机构信息

Department of Synthetic Chemistry and Biological Chemistry, Faculty of Engineering, Kyoto University, Japan.

出版信息

Nucleic Acids Symp Ser. 1995(34):33-4.

PMID:8841538
Abstract

The preparation and thermodynamic property of 8-methylguanine (8mG)-containing oligonucleotides were described. It was found that the introduction of a methyl group at the guanine C8 position remarkably stabilizes the Z conformation of short oligonucleotides of a variety of base sequences under low salt conditions.

摘要

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