在2'-糖基位置含有蒽醌的寡核苷酸与互补核酸的相互作用。
Interaction of oligonucleotides containing anthraquinone at the 2'-sugar position with complementary nucleic acids.
作者信息
Mitsui T, Yoshioka J, Isuno T, Yamana K, Nakano H
机构信息
Department of Applied Chemistry, Himeji Institute of Technology, Himeji, Japan.
出版信息
Nucleic Acids Symp Ser. 1995(34):35-6.
PMID:8841539
Abstract
Oligonucleotide 15-mers containing 2-anthraquinonylmethyl substituents at the different 2'-sugar residues have been synthesized. These oligomers exhibit increased stability in formation of hybrids with complementary DNA and RNA without loss of sequence specificity.
摘要
已合成了在不同2'-糖残基处含有2-蒽醌基甲基取代基的15聚体寡核苷酸。这些寡聚物在与互补DNA和RNA形成杂交体时表现出更高的稳定性，且不丧失序列特异性。
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