胸腺嘧啶基和腺嘌呤基吡咯烷酰胺寡核苷酸模拟物（POM）的核酸结合特性
Nucleic acid binding properties of thyminyl and adeninyl pyrrolidine-amide oligonucleotide mimics (POM).
作者信息
Tan T H Samuel, Hickman David T, Morral Jordi, Beadham Ian G, Micklefield Jason
机构信息
Department of Chemistry, University of Manchester Institute of Science and Technology, PO Box 88, Manchester, UK M60 1QD.
出版信息
Chem Commun (Camb). 2004 Mar 7(5):516-7. doi: 10.1039/b315768g. Epub 2004 Jan 28.
DOI:10.1039/b315768g
PMID:14973585
Abstract
Adeninyl POM was prepared using solid-phase peptide chemistry and shown to exhibit higher affinity for complementary DNA and RNA than the corresponding adeninyl PNA.
摘要
使用固相肽化学法制备了腺苷酰化的肽核酸（Adeninyl POM），结果表明其对互补DNA和RNA的亲和力高于相应的腺苷酰化肽核酸（PNA）。
相似文献
1
Nucleic acid binding properties of thyminyl and adeninyl pyrrolidine-amide oligonucleotide mimics (POM).胸腺嘧啶基和腺嘌呤基吡咯烷酰胺寡核苷酸模拟物（POM）的核酸结合特性
Chem Commun (Camb). 2004 Mar 7(5):516-7. doi: 10.1039/b315768g. Epub 2004 Jan 28.
2
Mixed-sequence pyrrolidine-amide oligonucleotide mimics: Boc(Z) synthesis and DNA/RNA binding properties.混合序列吡咯烷-酰胺寡核苷酸模拟物：Boc(Z)合成及DNA/RNA结合特性
Org Biomol Chem. 2007 Jan 21;5(2):249-59. doi: 10.1039/b613386j. Epub 2006 Dec 1.
3
Homopolymeric pyrrolidine-amide oligonucleotide mimics: Fmoc-synthesis and DNA/RNA binding properties.同聚吡咯烷酰胺寡核苷酸模拟物：芴甲氧羰基合成及DNA/RNA结合特性
Org Biomol Chem. 2007 Jan 21;5(2):239-48. doi: 10.1039/b613384n. Epub 2006 Dec 1.
4
Biophysical and cellular-uptake properties of mixed-sequence pyrrolidine-amide oligonucleotide mimics.混合序列吡咯烷酰胺寡核苷酸类似物的物理化学性质和细胞摄取特性。
Chemistry. 2011 Dec 16;17(51):14429-41. doi: 10.1002/chem.201101950. Epub 2011 Nov 11.
5
Kinetically selective binding of single stranded RNA over DNA by a pyrrolidine-amide oligonucleotide mimic (POM).吡咯烷酰胺寡核苷酸模拟物（POM）对单链RNA的动力学选择性结合优于DNA。
Nucleosides Nucleotides Nucleic Acids. 2001 Apr-Jul;20(4-7):1169-72. doi: 10.1081/NCN-100002512.
6
RNA-selective cross-pairing of backbone-extended pyrrolidine-amide oligonucleotide mimics (bePOMs).骨架延伸的吡咯烷酰胺寡核苷酸模拟物（bePOMs）的RNA选择性交叉配对
Org Biomol Chem. 2008 Jan 7;6(1):92-103. doi: 10.1039/b714580m. Epub 2007 Nov 1.
7
Design, synthesis, conformational analysis and nucleic acid hybridisation properties of thymidyl pyrrolidine-amide oligonucleotide mimics (POM).胸苷基吡咯烷酰胺寡核苷酸模拟物（POM）的设计、合成、构象分析及核酸杂交特性
Org Biomol Chem. 2003 Oct 7;1(19):3277-92. doi: 10.1039/b306156f.
8
Pyrrolidine nucleic acids: DNA/PNA oligomers with 2-hydroxy/aminomethyl- 4-(thymin-1-yl)pyrrolidine-N-acetic acid.吡咯烷核酸：含2-羟基/氨甲基-4-(胸腺嘧啶-1-基)吡咯烷-N-乙酸的DNA/PNA寡聚物
Org Lett. 2001 May 3;3(9):1269-72. doi: 10.1021/ol0069655.
9
Stereospecific backbone methylation of pyrrolidine-amide oligonucleotide mimics (POM).吡咯烷酰胺寡核苷酸模拟物（POM）的立体特异性主链甲基化
Chem Commun (Camb). 2006 Apr 7(13):1436-8. doi: 10.1039/b518171b. Epub 2006 Feb 23.
10
A theoretical analysis of specificity of nucleic acid interactions with oligonucleotides and peptide nucleic acids (PNAs).核酸与寡核苷酸及肽核酸（PNA）相互作用特异性的理论分析。
J Mol Biol. 1998 Feb 13;276(1):57-70. doi: 10.1006/jmbi.1997.1497.
引用本文的文献
1
Perspectives on conformationally constrained peptide nucleic acid (PNA): insights into the structural design, properties and applications.构象受限肽核酸（PNA）的展望：对结构设计、性质及应用的见解
RSC Chem Biol. 2022 Mar 18;3(6):648-697. doi: 10.1039/d2cb00017b. eCollection 2022 Jun 8.
2
Pyrrolidinyl peptide nucleic acid with α/β-peptide backbone: A conformationally constrained PNA with unusual hybridization properties.具有α/β-肽主链的吡咯烷基肽核酸：一种具有异常杂交特性的构象受限肽核酸。
Artif DNA PNA XNA. 2011 Apr;2(2):50-59. doi: 10.4161/adna.2.2.16340.
Zotero 插件