一种保护鸟苷O6位的新策略。
A novel strategy for O6-protection of guanosine.
作者信息
Kumar P, Dubey K K, Singh R K, Misra K
机构信息
Department of Chemistry, University of Allahabad, India.
出版信息
Nucleic Acids Symp Ser. 1995(34):51-2.
PMID:8841547
Abstract
A "one-pot reaction" has been used for simultaneous protection of amino and O6-function of deoxyguanosine. N-(4-bromobutyl) phthalimide used for O6-protection generates an alkylamino function after mild base hydrolysis. Two sequences d(GGA) and d(GGATCC) have been synthesised with all protected guanosine units. Similarly, 2-(vinyl)pyridine has also been used for O6-protection following the same strategy.
摘要
“一锅法反应”已用于同时保护脱氧鸟苷的氨基和O6位功能。用于O6保护的N-(4-溴丁基)邻苯二甲酰亚胺在温和的碱水解后会生成烷基氨基功能。已合成了具有所有保护鸟苷单元的两条序列d(GGA)和d(GGATCC)。同样，2-(乙烯基)吡啶也按照相同策略用于O6保护。
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